Screening of prolyl endopeptidase inhibitors from natural products PDF Print E-mail

Lee S-Y, Lee J-H, Hahn T-R, Paik Y-S: Screening of prolyl endopeptidase inhibitors from natural products. Agricultural Chemistry and Biotechnology 2002, 45(4):208-210.

Prolyl endopeptidase (PEP, EC 3.4.21.26) plays an important role in the degradation of biologically active proline-containing neuropeptides such as vasopressin, substance P, and thyrotropin-releasing hormone (TRH) and has been speculated to participate in learning and memory processes. In the course of search for anti-amnestic constituents, 105 fractions were prepared from 20 traditional medicinal plants and screened for PEP inhibitors. Specified fractions of Eugenia caryophyllata (flos), Ganoderma lucidumn (fungus), Ginkgo biloba (folium), Paeonia suffruticosa (cortex), Pueraria thunbergiana (flos), and Rhodiola sachalinensis (radix) showed 54-99% PEP inhibitory activities at 4 mug/ml.

 

Swissmedic registriertes Rhodiola Produkt: Erhältlich in Apotheken und Drogerien