Neuroprotective effects of constituents of the Oriental crude drugs, Rhodiola sacra, R. sachalinensis and Tokaku-joki-to, against beta-amyloid toxicity, oxidative stress and apoptosis PDF Print E-mail

Inhee M-J, Kim H, Fan W, Tezuka Y, Kadota S, Nishijo H, Jung MW: Neuroprotective effects of constituents of the Oriental crude drugs, Rhodiola sacra, R. sachalinensis and Tokaku-joki-to, against beta-amyloid toxicity, oxidative stress and apoptosis. Biological and Pharmaceutical Bulletin 2002, 25(8):1101-1104.

We tested the constituents of two Rhodiola plants, Rhodiola sacra S. H. Fu and R. sachalinensis A. BOR, and an Oriental crude drug, Tokaku-joki-to, for their neuroprotective effects. Of the 58 compounds tested, six had considerable protective effects against beta-amyloid-induced death of B103 neuronal cells in vitro. These six compounds also showed protective effects against staurosporine-induced cell death, and two of the six compounds protected neurons from H2O2-induced cell death. These results suggest that some of the tested compounds protect neurons from beta-amyloid toxicity based on antiapoptotic and antioxidative activity.

 

Swissmedic registriertes Rhodiola Produkt: Erhältlich in Apotheken und Drogerien