The effect of rhodiola and acetazolamide on the sleep architecture and blood oxygen saturation in men living at high altitude PDF Print E-mail

Ha Z, Zhu Y, Zhang X, Cui J, Zhang S, Ma Y, Wang W, Jian X: The effect of rhodiola and acetazolamide on the sleep architecture and blood oxygen saturation in men living at high altitude. Zhonghua Jiehe He Huxi Zazhi 2002, 25(9):527-530.

Objective: To study the changes of sleep architecture and blood oxygen saturation (SaO2) during sleep in men living at high altitude, and to investigate the effect of rhodiola and acetazolamide on these sleep indexes. Methods: Twenty-four men aged 18 to 21 years who had stayed at high altitude (5 380 m above sea level) for 1 year were randomly divided into groups A (treated with oral rhodiola), B (treated with oral acetazolamide) and C (treated with rhodiola+acetazolamide). Their sleep architecture and SaO2 were recorded for 24 days before and after taking the medicines. Results: Compared with baseline, the waking SaO2 (WSaO2), the lowest SaO2(LSaO2) and the mean SaO2(MSaO2) were increased significantly after treatment for 24 days (P<0.01), and the times of oxygen desaturation gtoreq4% per hour (DI4) and the percentage of time spent at SaO2 below 80% (SIT80) were decreased significantly (P<0.01). After treatment, the NREM I and II was shortened, and III+IV and REM sleep were prolonged (P<0.01): the total waking time (TWT) was shortened, and the sleep efficiency index (SEI) was markedly increased (P<0.01). Compared with group As, groups Bs and Cs SIT80 were increased (P<0.05). Conclusion Both rhodiola and acetazolamide were effective in modulating the sleep architecture and improving the sleep quality in young men living at high altitude, but there was no synergistic effect between rhodiola and acetazolamide.

 

Swissmedic registriertes Rhodiola Produkt: Erhältlich in Apotheken und Drogerien