Effect of Some Flavonoids on the Ulcerogenic Action of Reserpine in Mice PDF Print E-mail

Barnaulov OD, Manicheva OA, Zapesochnaya GG, Shelyuto VL, Glyzin VI: Effect of Some Flavonoids on the Ulcerogenic Action of Reserpine in Mice. Khimiko-Farmatsevticheskii Zhurnal 1982, 16(3):300-303.

The capacity of 11 flavonoids and the inhibitor of catechol-o-methyltransferase (COMT), depaverine to decrease the ulcerogenic action of reserpine in mice was evaluated. Herbacetin (isolated from Rhodiola algida) and quercetin had the most constantly expressed protective effect; luteolin, quercitrin, hyperin and depaverine were less effective; quercetin acetate, rutin, isoquercitrin (isolated from Sorbus tianschanica), cinaroside (isolated from Salix acutifolia), linarin [isolated from Cirsium deraceum) and (+)-catechin (isolated from Aflatunia ulmifolia) were inactive. The adreno-prolonging action, studied in isolated rabbit intestine sections, was not correlated with the antialterant activity of the preparations. The COMT-inhibiting and adrenoprolonging effects were not the only mechanisms of antialterant action of the flavonoids. In clinical practice, quercetin should be more effective than rutin. A method was described which made it possible to evaluate the antiulcerogenic activity of a preparation in mice in the presence of dg quantities.


Swissmedic registriertes Rhodiola Produkt: Erhältlich in Apotheken und Drogerien